Publications

Publications

Perform a customized PubMed literature search for Dr. David Brow.

  1. Bae E, Reiter NJ, Bingman CA, Kwan SS, Lee D, Phillips GN, Butcher SE, Brow DA (2007). Structure and ineractions of the first three RNA recognition motifs of splicing facor prp 24. J Mol Biol. 2007 Apr 13;367(5):1447-58. Pub Med
  2. Steinmetz EJ, Warren CL, Kuehner JN, Panbehi B, Ansari AZ, Brow DA (2006). Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase. Mol Cell. 2006 Dec 8;24(5):735-46. Pub Med
  3. Kuehner JN, Brow DA (2006). Quantitative analysis of in vivo initiator selection by yeast RNA polymerase II supports a scanning model. J Biol Chem. 2006 May 19;281(20):141190 28. Pub Med
  4. Steinmetz EJ, Ng SB, Cloute JP, Brow DA. cis- and trans-Acting determinants of transcription termination by yeast RNA polymerase II. Mol Cell Biol. 2006 Apr;26(7):2688-96. Pub Med
  5. Butcher SE, Brow DA. Towards understanding the catalytic core structure of the spliceosome. Biochem Soc Trans. 2005 Jun;33(Pt 3):447-9. Pub Med
  6. Kwan SS, Brow DA. The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding. RNA. 2005 May;11(5):808-20. Pub Med
  7. Sashital DG, Cornilescu G, McManus CJ, Brow DA, Butcher SE. U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction. Nat Struct Mol Biol. 2004 Dec;11(12):1237-42. Pub Med
  8. Steinmetz EJ, Brow DA. Ssu72 protein mediates both poly(A)-coupled and poly(A)-independent termination of RNA polymerase II transcription. Mol Cell Biol. 2003 Sep;23(18):6339-49. Pub Med
  9. Brow DA. Allosteric cascade of spliceosome activation. Annu Rev Genet. 2002;36:333-60. Pub Med
  10. Kuhn, A.N., Reichl, E.M., and Brow, D.A. (2002). Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation. Proc. Natl. Acad. Sci. USA 99, 9145-9149. Pub Med
  11. Huppler, A., Nikstad, L.J., Allmann, A.M., Brow, D.A., and Butcher, S.E. (2002). Essential metal ion binding and base ionization in the structure of the U6 RNA intramolecular stem-loop. Nature Struct. Biol. 9, 431-435. Pub Med
  12. Steinmetz, E.J., N.K. Conrad, D.A. Brow, and J.L. Corden. (2001). RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts. Nature 413: 327-331. Pub Med
  13. Martin, M.P., V.L. Gerlach, and D.A. Brow. (2001). A novel upstream RNA polymerase III promoter element becomes essential when the chromatin structure of the yeast U6 RNA gene is altered. Molec. Cell. Biol. 21, 6429-6439. Pub Med
  14. Kwan, S., V.L. Gerlach and D.A.Brow. (2000). Disruption of the 5? stem-loop of yeast U6 RNA induces trimethylguanosine capping of this RNA polymerase III transcript in vivo. RNA 6: 1859-1869. Pub Med
  15. Kuhn, A.N. and D.A. Brow. 2000. Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155: 1667-1682. Pub Med
  16. Conrad, N.K., S.M. Wilson, E.J. Steinmetz, M. Patturajan, D.A. Brow, M.S. Swanson, andJ.L. Corden. 2000. A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II. Genetics 154: 557-571. Pub Med
  17. Vidaver, R.M., D.F. Fortner, L.S. Loos-Austin, and D.A. Brow. 1999. Multiple functions of Saccharomyces cerevisiae splicing protein Prp24 in U6 RNA structural rearrangements. Genetics 153: 1205-1218. Pub Med
  18. Kuhn, A.N., Z. Li, and D.A. Brow. 1999. Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome. Molec. Cell 3: 65-75. Pub Med
  19. Steinmetz, E.J., and D. A. Brow. 1998. Control of pre-mRNA accumulation by the essential yeast protein Nrd1 requires high-affinity transcript binding and a domain implicated in RNA polymerase II association. PNAS 95: 6699-6704. Pub Med
  20. Steinmetz, E.J. 1997. Pre-mRNA processing and the CTD of RNA polymerase II: the tail that wags the dog? Cell 89: 491-494. Pub Med
  21. Steinmetz, E.J., and D. A. Brow. 1996. Repression of gene expression by an exogenous sequence element acting in concert with a heterogenous nuclear ribonucleoprotein like protein, Nrd1, and the putative helicase Sen1. Molecular and Cellular Biology 16: 6993-7003. Pub Med
  22. Li, Z., and D. A. Brow. 1996. A spontaneous duplication in U6 spliceosomal RNA uncouples the early and late functions of the ACAGA element in vivo. RNA 2: 879 - 894. Pub Med
  23. Kaiser, M.K., and D.A. Brow. 1995. Lethal mutations in a yeast U6 RNA gene B block promoter element identify essential contacts with transcription factor-IIIC. Journal of Biological Chemistry. 270(19): 11398-11405. Pub Med
  24. Brow, D.A., and R.M. Vidaver. 1995. An element in human U6 RNA destabilizes the U4/U6 spliceosomal complex. RNA 1:122-131. Pub Med
  25. Gerlach, V.L., S.K. Whitehall, E.P. Geiduschek, and D.A. Brow. 1995. TFIIIB placement on a yeast U6 RNA gene in vivo is directed primarily by TFIIIC rather than by sequence-specific DNA contacts. Molecular and Cellular Biology 15: 1455-1455. Pub Med
  26. Fortner, D.M., R.G. Troy, and D.A. Brow. 1994. A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing. Genes and Development 8: 221-233. Pub Med
  27. Li, Z. and D.A. Brow. 1993. A rapid assay for quantitative detection of specific RNAs. Nucleic Acids Research 21: 4645-4646. Pub Med
  28. Eschenlauer, J.B., M.W. Kaiser, V.L. Gerlach, and D.A. Brow. 1993. Architecture of a yeast U6 RNA gene promoter. Molecular and Cellular Biology 13: 3015-3026. Pub Med