Deane Mosher

Professor 4285 Medical Sciences Center 1300 University Avenue Madison WI 53706-1532 Phone: (608) 262-4455 Fax: (608) 263-4969 dfm1@medicine.wisc.edu The Mosher Lab

Education

• M.D. 1968, Harvard Medical School
• Postdoctoral 1970-72, Harvard Medical School (Elkan Blout).

Honors & Awards

• 1997 - R.F. Schilling WARF Professor
• 1982-87 - H.I. Rommes Fellow

Research Interests

Publications of Note

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1. Annis DS, Gunderson KA, Mosher DF. Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations. Papers In Press. J. Biol. Chem., Jul 2007;
2. Barthel SR, Annis DS, Mosher DF, Johansson MW. Differential engagement of modules 1 and 4 of VCAM-1 (CD106) by integrins alpha4 beta1 (CD49d/29) and alphaM beta2 (CD11b/18) of eosinophils. J Biol Chem 281:32175-87, 2006.
3. Cho J, Mosher DF. Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor. Blood, 108:2229-36, 2006
4. Barthel SR, Jarjour NN, Mosher DF, Johansson MW. Dissection of the hyper-adhesive phenotype of airway eosinophils in asthma. Am J Resp Cell Mol Biol 35:378-86, 2006.
5. Barthel SR, Johansson MW, Annis DS, Mosher DF. Cleavage of human 7-domain VCAM-1 (CD106) by thrombin. Thromb Haemost 95:873-80, 2006.
6. Johansson MW, Barthel SR, Swenson CA, Evans MD, Jarjour NN, Mosher DF, Busse WW. Eosinophil b1 integrin activation state correlates with asthma activity in a blinded study of inhaled corticosteroid withdrawal. J Allergy Clin Immunol 117:1502-4, 2006.
7. Cho J, Mosher DF. Characterization of fibronectin assembly by platelets adherent to adsorbed laminin-111. J Thromb Haemost 4:943-51, 2006.
8. Tomasini-Johansson BR, Annis DS, Mosher DF. The N-terminal 70-kDa fragment of fibronectin binds to cell surface fibronectin assembly sites in the absence of intact fibronectin. Matrix Biol 25:282-93, 2006.
9. Cho J, Mosher DF. Enhancement of thrombogenesis by plasma fibronectin crosslinked to fibrin and assembled in platelet thrombi. Blood 107:3555-63, 2006
10. Annis DS, Murphy-Ullrich JE, Mosher DF. Function-blocking anti-thrombospondin-1 monoclonal antibodies. J Thromb Haemost, 4:459-68, 2006.
11. Misenheimer T, Mosher DF. Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2. J Biol Chem, 280:41229-35, 2005.
12. Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL. Structure of the calcium-rich signature domain of human thrombospondin-2. Nat Struct Mol Biol 12:910-4, 2005.
13. Cho J, Degen JL, Coller BS, Mosher DF. Fibrin but not absorbed fibrinogen supports fibronectin assembly by spread platelets: effects of the interaction of aIIbb3 with the C-terminus of the fibrinogen g-chain. J Biol Chem, 280:35490-8, 2005.
14. Hannah BL, Misenheimer TM, Pranghofer MM, Mosher DF. A polymorphism in thrombospondin-1 associated with familial premature coronary artery disease alters Ca2+ binding. J Biol Chem 279:51915 - 22, 2004.
15. Calzada MJ, Annis DS, Zeng B, Marcinkiewicz C, Banas B, Lawler J, Mosher DF, Roberts DD. Identification of novel beta-1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1 J Biol Chem 279: 41734-43, 2004.
16. Ensenberger MG, Annis DS, Mosher DF. Actions of the functional upstream domain of protein F1 of Streptococcus pyogenes on the conformation of fibronectin Biophys Chem 112:201-7, 2004.
17. Johansson MW, Lye MH, Barthel SR, Duffy AK, Annis DS, Mosher DF. Eosinophils adhere to VCAM-1 via podosomes. Am J Resp Cell Mol Biol 31: 413-22, 2004.
18. Bae E, Sakai T, Mosher DF. Assembly of exogenous fibronectin by fibronectin-null cells is dependent on the adhesive substrate. J Biol Chem 279:35749-59, 2004.
19. Huwiler KG, Mosher DF, Vestling MM. Optimizing the MALDI-TOF-MS observation of peptides containing disulfide bonds. J Biomolecular Techniques 14:289-97, 2003.
20. Misenheimer TM, Hannah BL, Annis DS, Mosher DF. Interactions among the three structural motifs of the C- terminal region of human thrombospondin-2. Biochemistry 42:5125-32, 2003.
21. Hannah BL, Misenheimer TM, Annis DS, Mosher DF. A Polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca++ binding repeats. J Biol Chem 278: 8929-34, 2003.

University of Wisconsin - Department of Biomolecular Chemistry
First published: 01/01/05 Last updated: 08/15/07 Email Biomolecular Chemistry
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